YPmodelPhreg - The Short-Term and Long-Term Hazard Ratio Model with Proportional Adjustment

Provides covariate-adjusted comparison of two groups of right censored data, where the binary group variable has separate short-term and long-term effects on the hazard function, while effects of covariates such as age, blood pressure, etc. are proportional on the hazard. The model was studied in Yang and Prentice (2015) <doi:10.1002/sim.6453> and it extends the two sample version of the short-term and long-term hazard ratio model proposed in Yang and Prentice (2005) <doi:10.1093/biomet/92.1.1>. The model extends the usual Cox proportional hazards model to allow more flexible hazard ratio patterns, such as gradual onset of effect, diminishing effect, and crossing hazard or survival functions. This package provides the following: 1) point estimates and confidence intervals for model parameters; 2) point estimate and confidence interval of the average hazard ratio; and 3) plots of estimated hazard ratio function with point-wise and simultaneous confidence bands.

Last updated 2 years ago

1.70 score 5 scripts 138 downloads

EventWinRatios - Event-Specific Win Ratios for Terminal and Non-Terminal Events

Provides several confidence interval and testing procedures using event-specific win ratios for semi-competing risks data with non-terminal and terminal events, as developed in Yang et al. (2021<doi:10.1002/sim.9266>). Compared with conventional methods for survival data, these procedures are designed to utilize more data for improved inference procedures with semi-competing risks data. The event-specific win ratios were introduced in Yang and Troendle (2021<doi:10.1177/1740774520972408>). In this package, the event-specific win ratios and confidence intervals are obtained for each event type, and several testing procedures are developed for the global null of no treatment effect on either terminal or non-terminal events. Furthermore, a test of proportional hazard assumptions, under which the event-specific win ratios converge to the hazard ratios, and a test of equal hazard ratios are provided. For summarizing the treatment effect on all events, confidence intervals for linear combinations of the event-specific win ratios are available using pre-determined or data-driven weights. Asymptotic properties of these inference procedures are discussed in Yang et al (2021<doi:10.1002/sim.9266>). Also, transformations are used to yield better control of the type one error rates for moderately sized data sets.

Last updated 3 years ago

1.70 score 4 scripts 357 downloads